Silver as a Cure for Ebola - Literature Collection
- ebola, hemorrhagic, viruses, lassa, 2014, marburg, colloidal silver, cure, treatment, outbreak, pandemic, africa, USA, europe, isolation, disease, antiviral, tamiflu, adamantine, silver particles, silver ions, nano-silver, papers, DoD, biological weapon, transmission, technology, research
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This is very important, given the current uncontrolled outbreaks of Ebola (2014), and now their uncontrolled spread.
The most directly important of these papers is possibly the hard to find "Silver Nanoparticles as Potential Antiviral Agents" published by the Department of Defense. Here, the 10nm Ag particles are tested with Arenaviridae and Filoviridae, which are very strongly inhibited. The several mechanisms for this are explored also. In some of the other papers, it seems to be established that the active agent is silver ion, not the metallic silver itself.
There will be practically no interest in this on the part of major pharmaceutical manufacturers, as there is no possibility of a patent, or of effectively restricting the supply of this medication (and thereby artificially elevating the price). Therefore, manufacture and further testing will inevitably fall to those outside of that system. While it might seem surprising that something so simple would be effective, it is worth remembering that the very first effective antibiotic used to successfully treat any disease, was Louis Pasteur's "Salvarsan 606". Salvarsan was an organometallic compound, based on arsenic. Therefore, metals actually have the longest established history of all antimicrobials. Silver had also been used before this for centuries in the form of "Lunar Caustic", or silver nitrate. UPDATE: Since the most obvious effective treatment with silver would be IV injection of nano-silver/normal saline (or IV drip), bearing in mind that the Ebola virus does its damage from within the blood stream, literature is being included on the safety and history of silver as an injectable. Apparently, cumulative doses of up to 1 gram of silver have been administered before any threshold of chronic (benign) adverse effect (argyria). This is quite good, considering only 10ppm of 10nm nano-silver is shown to stop Ebola viral RNA replication, for example. UPDATE: China has approved a 'molecular' treatment (on an emergency basis) for Ebola treatment - the first approved treatment of any kind by a national government. Literature will be included. By their implication, it appears that this treatment is based on nano-silver of some kind. UPDATE: See "Simplified Arc-Discharge Production of Nano-Silver 10-25nm - Tien et al". This published method dramatically simplifies the scalable production of nano-silver of exactly the right particle sizes. The smaller particles are shown by the DoD paper to inhibit Ebola RNA synthesis, while the larger inhibit cell binding of the virus. Previous methods used tricky and slow borohydride reduction of AgNO3, followed by slow monochromatic light exposure. The traditional low-voltage electrode ('colloid') methods, tend to produce particle sizes too large. The arc method gives a major advantage over both. ===================== See also: https://archive.org/details/PlantMaterialsEbola
- 2014-10-08 06:18:29
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Subject: Good info and thanks
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